Bharat Biotech – Walk-in for Production/ Engineering departments on 25th Jan 2025

Experience: 2 to 7 Years of relevant experience
Qualification: ITI, Diploma / B Tech (Mech, ECE, EEE), Graduation, Post Graduation
Work Location: Hyderabad

*Note: Shifts Applicable

Job Description:

Job Description
Upstream Process

• Oversee the preparation and sterilization of media and buffers essential for bacterial and viral cultures.
• Manage the operation of bioreactors and fermenters to facilitate bacterial and viral growth, ensuring that optimal conditions such as temperature, pH, and oxygen levels are maintained.
• Continuously monitor and regulate critical parameters throughout the cell culture or fermentation processes.
• Conduct sampling, testing, and troubleshooting activities during the upstream phase.
• Document and analyze process data to enhance yield and operational efficiency.

Downstream Process

• Implement recovery and purification techniques, which include centrifugation, filtration, chromatography, and ultrafiltration/diafiltration.
• Manage the clarification, concentration, and formulation of both intermediate and final vaccine products.
• Conduct in-process quality control testing during downstream operations.
• Refine process parameters to attain the desired purity and potency of vaccines.

Compliance and Documentation

• Adhere to Good Manufacturing Practices (GMP), Standard Operating Procedures (SOPs), and biosafety regulations throughout all production activities.
• Compile and maintain comprehensive production records, batch records, and equipment logbooks.
• Support audit processes by providing necessary documentation and evidence to demonstrate regulatory compliance.

Equipment Operation and Maintenance

• Operate and maintain production equipment, including bioreactors, centrifuges, filtration units, and chromatography systems.
• Ensure that equipment is properly cleaned, sterilized, and calibrated in accordance with SOPs.
• Address minor technical issues and collaborate with the maintenance team for necessary repairs.

Qualifications: B Tech / Diploma / ITI
Experience: 2 to 7 Years

*Shifts Applicable

*Preferred candidates from Vaccines & Injectable Industries.

Job Responsibilities

1. Equipment Maintenance and Troubleshooting:

• Conduct routine and preventive maintenance on equipment utilized in vaccine production, including fermenters, bioreactors, autoclaves, vial filling lines, and utility systems.
• Diagnose, troubleshoot, and rectify equipment malfunctions to reduce operational downtime.

2. Process Optimization:

• Engage with production teams to improve equipment functionality and enhance process efficiency.
• Propose and implement engineering modifications aimed at increasing operational reliability.

3. Calibration and Validation:

• Perform regular calibration and validation of essential equipment to adhere to Good Manufacturing Practices (GMP) and regulatory standards.
• Ensure that all instruments meet the required precision and accuracy specifications.

4. Documentation and Compliance:

• Keep comprehensive records of maintenance activities, equipment logs, and calibration timelines.
• Ensure adherence to safety standards, environmental regulations, and compliance with regulatory bodies (FDA, WHO, etc.).

5. Support for New Installations:

• Assist in the installation, commissioning, and qualification of new machinery and equipment.
• Provide engineering support for the upgrades and expansions of current facilities.

6. Utility Management:

• Supervise and maintain essential utilities, including HVAC, water systems (WFI, RO), steam systems, and compressed air systems critical for vaccine production.

7. Team Collaboration:

• Collaborate closely with cross-functional teams, including Quality Assurance, Production, and Validation, to ensure smooth operational processes.
• Deliver training to production and maintenance personnel on equipment operation and safety procedures.

8. Instrumentation Maintenance and Calibration:

• Conduct regular maintenance, calibration, and troubleshooting of instruments used in vaccine manufacturing, such as pressure sensors, flow meters, pH probes, temperature sensors, and data loggers.
• Ensure that instruments comply with industry standards and regulatory requirements.

9. Automation Systems Management:

• Manage, operate, and monitor automation systems essential for the production process.

About Company:

Bharat Biotech International Limited (BBIL) is an Indian multinational biotechnology company based in Hyderabad, specializing in vaccine production and drug discovery. The company is a leader in developing vaccines for diseases such as Rotavirus, Hepatitis-B, Typhoid, and Polio.